The tumor suppressor protein p53, known as the “guardian of the genome,” protects the body’s DNA from daily stress or long-term damage by triggering cells to either repair or self-destruct. But mutations in the p53 gene that codes for this protein prevent it from working, allowing errors to accumulate in the genetic code, leading to diseases such as cancer. For the first time, a Penn State-led team has discovered the complete structure of the p53 protein using patient samples. They also investigated how mutation-induced changes in the structure of p53…
Complete 3D Structure of P53 Protein Found
